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In the multivariable model, other determined etiology (HR 5.69, 95% CI 1.50-15.98, p = 0.015), fluctuating symptoms (HR 3.74, 95% CI 1.67-8.65, p = 0.0015), and male sex (HR 2.88, 95% CI 1.23-7.70, p = 0.014) were independent predictors of IS, whereas year of treatment was not

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